DNA topology

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  • gyrB gyrB encodes DNA gyrase subunit B, a subunit of the enzymes the is responsible for negatively supercoiling DNA.
  • parE parE encodes DNA topoisomerase IV subunit B, a subunit of the enzymes the is responsible decatenating daughter DNA molecules, and uncoiling positive and negative DNA supercoils.
  • MMSYN1_0453,EG10686 parC encodes DNA Topoisomerase IV, subunit a. DNA Topoisomerase IV decatenates DNA strands that are linked together after replication. This is essential for chromosome segregation.
  • MMSYN1_0859,EG11013 topA encodes DNA Topoisomerase 1. This enzyme is responsible for relaxing torsional tension and supercoiled DNA that has been generated through replication or translation.