Protein folding

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  • yidC JCVI Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
  • yidC E.coli Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
  • DJ-1 family protein- A protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Protein deglycase DJ-1 is in humans encoded by PARK7 and known as Parkinson disease protein 7.
  • yajL (E.Coli)- has now been identified as a protein deglycase that repairs glyoxal- and methylglyoxal-glycated proteins. It forms mixed disulfides with cellular proteins in response to oxidative stress; its cellular targets include a number or ribosomal proteins as well as members of the cellular thiol proteome, including aconitase and Fe-S cluster-containing subunits of dehydrogenases.