Syncells

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The JCVI-Syn3.0 synthetic cells reported by C.A. Hutchison III et al. in 2016 [1] are documented at the JCVI website. The cell line is commercially available from SGI-DNA. Note that these cells can be purchased for research use; the cost is $1,875.

The authors of the minimal genome paper recently released a perspectives paper, outlining their view on synthetic cells, in Minimal Cells—Real and Imagined.[2] It provides a good overview of the history of the field, and the potential that lies in identifying genes of unknown function in JCVI-Syn3.0.

The database of genes analysed in Design and synthesis of a miminal bacterial genome, and of genes used in the final JCVI-Syn3.0 design, is available at http://science.sciencemag.org/highwire/filestream/676725/field_highwire_adjunct_files/1/aad6253-Hutchison-SM-database-S1.xlsx. A copy of the database is also available at File:Aad6253-Hutchison-SM-database-S1.xlsx.

References

  1. C.A. Hutchison III et al. Design and synthesis of a minimal bacterial genome. Science. Vol. 351, March 25, 2016, p.1414. doi: 10.1126/science.aad6253
  2. Glass, John I., et al. "Minimal Cells—Real and Imagined." Cold Spring Harbor Perspectives in Biology (2017): a023861.