TRNA modification

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  • LysS encodes lysine-tRNA synthetase, the aminoacyl-tRNA synthetase that bonds L-lysine to its cognate tRNA prior to translation initiation.
  • TilS (MMSYN1_0040) encodes tRNAIle-lysidine synthetase, the enzyme responsible for modifying the wobble base of the CAU anticodon of tRNAIle such that if can recognize the AUA codon rather than the AUG codon.
  • TilS (G6096) encodes tRNAIle-lysidine synthetase, the enzyme responsible for modifying the wobble base of the CAU anticodon of tRNAIle such that if can recognize the AUA codon rather than the AUG codon.
  • T6A_YjeE facilitates codon-anticodon pairing and prevents frameshifting during protein synthesis.
  • trmFO catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
  • truA: The truA gene encodes the tRNA pseudouridine(38-40) synthase enzyme, which catalyzes the reaction of uridine(38-40) in tRNA to pseudouridine(38-40) in tRNA at positions 38-40 in the anticodon loop. Exact function of pseudouridination of tRNAs is unknown.
  • truA: The truA gene encodes the tRNA pseudouridine38-40 synthase enzyme, which catalyzes the reaction of tRNA uridine(38-40) to tRNA pseudouridine(38-40), forming pseudouridine at positions 38, 39, and 40 in the tRNA anticodon stem and loop. Exact function of pseudouridination of tRNAs is unknown.
  • truB: truB catalyzes the synthesis of pseudouridine from uracil-55 in tRNA.
  • truB: truB catalyzes the synthesis of pseudouridine from uracil-55 in tRNA.
  • dusB: dusB codes for a gene that helps catalyze the reduction of uridine residue on tRNA.
  • dusB: As it does in all contexts, dusB codes for a gene that very specifically helps catalyze the reduction of uridine residue on tRNA.
  • dusB: In general, based on knowledge of E.Coli dusB functionality, dusB works with dusA and dusC to catalyze the reduction of uridine in tRNA, modifying the 5,6-dihydrouridine. However, more research is being done currently to figure out exact specifications.
  • dusB: dusB works with dusA and dusC to catalyze the reduction of uridine in tRNA, modifying the 5,6-dihydrouridine.
  • thiI JCVI, thiI E.coli encodes for an enzyme that catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNA.
  • t6A_YeaZ encodes for a protein with regulatory activity that is associated with t6A tRNA modification.
  • tsaB encodes for a subunit protein that is part of a polymer that is involved in the biosynthesis of the t6A residue at position 37 of ANN-decoding tRNAs.
  • tsaC: tsaC helps synthesize threonylcarbamoyl-AMP, which helps biosynthesize the t6A modification at position 37 of ANN-decoding tRNAs.
  • tsaD required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. It is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.
  • trmU Catalyzes formation of the 2-thiouridine modification of the modified nucleoside 5-methylamino-methyl-2-thiouridine (mnm5s2U34) in the wobble position of tRNA.
  • GltX GltX catalyzes glutamine reactions by linking amino acids to their specific tRNA molecules in a reaction driven by ATP hydrolysis.
  • trmH (Ecoli) is part of the spoU family. It acts the same way as trmH but in the Ecoli cell.
  • trmD- methyltransferase catalyzes the addition of a methyl group to G37 of certain tRNAs.
  • trmD (E. Coli)- in E. Coli was also a gene noticed as essential for growth as well as catalyzing methyltransferase.
  • cysS cysS encodes Cysteine-tRNA ligase (CysRS), which interprets the genetic code by covalently linking amino acids to their specific tRNA molecules.
  • cysS cysS encodes Cysteine-tRNA ligase (CysRS), which interprets the genetic code by covalently linking amino acids to their specific tRNA molecules.